Pluripotent stem cells used for regenrative medicine risks. They can develop mutations that favor the production of cancer cells

It should be crucial to check pluripotent cell lines (embryonic and iPS cells) before clinical testing before their use in regenerative medicine The production of pluripotent stem cells, from which virtually all types of cells can be obtained, may be of great use for the...

The future of iPS – induced pluripotent stem cells. New finding increases tremendously their potential for clinical use

Cells now can be obtained from anonymous donors, however, and stored in a cell bank, the costs would be reduced significantly, and their potential for clinical use would increase tremendously A recent article published in Nature discussed some specific aspects regarding the...

Eggs and sperm could be produced from female blood samples

The journal Science has published an interesting article  by a Japanese group, led by Mitonori Saitou, which describes the production of oogonia from female blood cells. According to Carlos Simón, an expert in this area (see HERE ), “a mature oocyte has not yet been obtained,...

In vivo cell reprogramming. A major step forward in regenerative medicine

Cell reprogramming  is revolutionizing the biomedical world, not only because it can obtain cells of different tissues from pluripotent cells, but also because these cells can be genetically modified to be used for the treatment of serious illnesses or to better understand them,...

Neuroscience. New experiments with brain rekindle the bioethical debate

Neuroscience research, with the ultimate goal of deepening our knowledge of the human brain, about which we still know so little, is advancing rapidly (see HERE). Thus, major projects such as the “BRAIN Initiative” in the United States and the Human Brain Project (HBP) in Europe...

Pulmonary organoids produced from human iPS cells in three dimensions (3D)

Lung organoids have been produced from human pluripotent stem (iPS) cells that contain various components of lung tissue, and even airways and alveolar structures (see HERE). Recapitulation of lung development from human pluripotent stem cells (hPSCs) in three dimensions (3D)...

Ten years since the discovery of iPS cells. The current state of their clinical application

  Rev Clin Esp. 2017 Jan – Feb;217(1):30-34. doi: 10.1016/j.rce.2016.08.003. Epub 2016 Oct 5. Justo Aznar Ph.D. MD Julio Tudela Pharm Ph.D. Institute of Life Science – Bioethics Observatory Catholic University of Valencia – Spain iPS cells current clinical...

Stem cell research. The two sides of the coin

Science facing market The “heads” of stem cell research Stem cells today represent a great hope for the future of regenerative medicine due to their ability to differentiate into cell lines of almost any tissue, making them a promising therapeutic option for many...

Serotonin produced from neurons obtained with iPS and embryonic stem cells

Serotonin is implicated in functions as important as humour, sadness, feelings of aggression, anxiety and sleep disturbances, among others. A deficiency in serotonin release has been related with schizophrenia, depression, bipolar disorder, obsessive-compulsive disorders, chronic...

New advances and challenges in the production of human-animal chimeras

They had overcome the obstacle of using human embryonic stem cells, but that even so, a ethical difficulty remained with the producing organs formed almost entirely of human cells in experimental animals. It seems a little excessive that, in less than two months, we have...