US authorizes the use of CRISPR directly in the patient’s body, until now the trials was made in cells extracted of the patient

Hopes and and concerns The first clinical trial involving the use of the gene editing tool CRISPR directly in the patient (see more ) has been approved in the United States. The trial aim to treat a congenital blindeness will include around 15 patients, adults and children, in...

Around the debate of CRISPR human experiments. New global registry is proposed and a moratorium in reproductive germline editing

There’s an “urgent need” to create a transparent global registry that would list all experiments related to human genome editing, an expert committee convened to advise the World Health Organization (WHO) said today. The international committee of 18 researchers and bioethicists,...

CRISPR-mediated therapeutic editing corrects a genetic disease in mice’s fetuses. May it pave way in humans?

Researchers at the Children’s Hospital of Philadelphia Institute (CHOP) and the University of Pennsylvania have published the first proof-of-concept demonstrating the possibility of using CRISPR gene editing to cure diseases in utero (Nature Medicine). Using this strategy, they...

“Gene-edited babies” in China. What has said the coinventor of CRISPR technique, Jennifer Doudna?

Jennifer Doudna said, “It is a matter of when and where the gene editing technology will be used in human embryos”. As we commented HERE a Chinese scientist claimed he has used the CRISPR gene-editing science to produce two infants who will be resistant to HIV...

Cocaine effects and overdose successfully treated with CRISPR gene editing in mice

Researchers at the University of Chicago have used the CRISPR gene editing tool to treat cocaine addiction in mice, and suggest that it will be feasible to use this treatment in people. Methodology. Producing an artificial enzyme  The study, published in Nature Biomedical...

CRISPR-Cas9 causes more damage in the genome than thought

At present CRISPR-Cas9  produces off-target effects See video below The CRISPR-Cas9 genome editing system causes more damage in the cellular DNA than previously believed, and this is not detected by standard tests, according to a study published in Nature Biotechnology. While it...

CRISPR-Cas9, the gene editing tool, might cause cancer. Why does Crispr present difficulties in humans?

Editing cells’ genomes with CRISPR-Cas9  might increase the risk that the altered cells, intended to treat disease, will trigger cancer, two studies published on Monday warn [2018, Jun 11]— a potential game-changer for the companies developing CRISPR-based therapies. (Begley,...

Duchenne muscular dystrophy could be treated with genome editing using CRISPR/Cas9 technique

Genome editing using  CRISPR/Cas9 is a promising possibility for correcting diseases due to genetic mutations (see HERE ), such as Duchenne muscular dystrophy – lethal degeneration of cardiac and skeletal muscle caused by different genetic mutations (see more HERE), which...

CRISPR-Cas9 brings the possibility of performing pig-to-human xenotransplantation closer

Use chimeric animals as organ incubators, a hopeful means to resolve increasing organ shortage The shortage of human organs and tissues for transplantation represents one of the most critical unmet medical needs today. To address this problem, xenotransplantation, i.e. the use of...

CRISPR: the genome editing tool reveals the keys to embryonic development

At the beginning of 2016, the United Kingdom Human Fertilisation and Embryology Authority (HFEA) announced that it had approved a request from the Francis Crick Institute to use the new genome-editing techniques in human embryos for the first time in the country. The aim was to...