Promising experiment with CRISPR. It corrects a lung disease in mouse fetuses but this research still has certain limitations

One step forward in the possibility of applying CRISPR in utero to correct diseases The CRISPR gene editing tool has been applied in utero in mice to correct a mutation that causes a lethal lung disease in mice. These experiments, published recently in Science Translational...

Could CRISPR gene editing tool eradicate entire species? Spanish Institute releases a campaign to eradicate cockroache

Could cockroaches enter in the category of endangered species? Researchers at the Institute of Evolutionary Biology in Barcelona want to use the CRISPR gene editing tool to eradicate cockroaches. The strategy would consist of expanding a harmful genetic trait (sterility) in the...

US authorizes the use of CRISPR directly in the patient’s body, until now the trials was made in cells extracted of the patient

Hopes and and concerns The first clinical trial involving the use of the gene editing tool CRISPR directly in the patient (see more ) has been approved in the United States. The trial aim to treat a congenital blindeness will include around 15 patients, adults and children, in...

Around the debate of CRISPR human experiments. New global registry is proposed and a moratorium in reproductive germline editing

There’s an “urgent need” to create a transparent global registry that would list all experiments related to human genome editing, an expert committee convened to advise the World Health Organization (WHO) said today. The international committee of 18 researchers and bioethicists,...

CRISPR-mediated therapeutic editing corrects a genetic disease in mice’s fetuses. May it pave way in humans?

Researchers at the Children’s Hospital of Philadelphia Institute (CHOP) and the University of Pennsylvania have published the first proof-of-concept demonstrating the possibility of using CRISPR gene editing to cure diseases in utero (Nature Medicine). Using this strategy, they...

“Gene-edited babies” in China. What has said the coinventor of CRISPR technique, Jennifer Doudna?

Jennifer Doudna said, “It is a matter of when and where the gene editing technology will be used in human embryos”. As we commented HERE a Chinese scientist claimed he has used the CRISPR gene-editing science to produce two infants who will be resistant to HIV...

Cocaine effects and overdose successfully treated with CRISPR gene editing in mice

Researchers at the University of Chicago have used the CRISPR gene editing tool to treat cocaine addiction in mice, and suggest that it will be feasible to use this treatment in people. Methodology. Producing an artificial enzyme  The study, published in Nature Biomedical...

CRISPR-Cas9 causes more damage in the genome than thought

At present CRISPR-Cas9  produces off-target effects See video below The CRISPR-Cas9 genome editing system causes more damage in the cellular DNA than previously believed, and this is not detected by standard tests, according to a study published in Nature Biotechnology. While it...

CRISPR-Cas9, the gene editing tool, might cause cancer. Why does Crispr present difficulties in humans?

Editing cells’ genomes with CRISPR-Cas9  might increase the risk that the altered cells, intended to treat disease, will trigger cancer, two studies published on Monday warn [2018, Jun 11]— a potential game-changer for the companies developing CRISPR-based therapies. (Begley,...

Duchenne muscular dystrophy could be treated with genome editing using CRISPR/Cas9 technique

Genome editing using  CRISPR/Cas9 is a promising possibility for correcting diseases due to genetic mutations (see HERE ), such as Duchenne muscular dystrophy – lethal degeneration of cardiac and skeletal muscle caused by different genetic mutations (see more HERE), which...