Every genetic disease is traditionally associated with one gene bit now a study has been published suggesting that one gene links unrelated diseases playing a role in Parkinson’s disease and Crohn’s disease, a serious bowel disorder. The team found a link between Crohn’s disease and a particular DNA sequence in a gene called LRRK2. The variant DNA causes the LRRK2 protein to become more active than the typical protein — as does a Parkinson’s disease-associated variant in the same part of the protein. The researchers say that the findings could help to explain the mechanism underlying the two seemingly unrelated diseases. Icahn School of Medicine at Mount Sinai in New York have established this relationship after analyzing 2,000 patients with Crohn’s disease and 3,600 without the condition, all belonging to the Ashkenazi Jewish population (Nature, 11 JANUARY 2018 see HERE ).
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